Fri, 11/10/2019 - 4:00pm
RC-2063, The Red Centre, UNSW
The vast array of animal form and function has little to do with what genes are present in each species, but depends instead on how they are regulated. This information is unfurled as development progresses with cell lineage-specific gene regulatory networks (GRNs) leading to spatial and temporal patterns of cell-type specific expression profiles. The activation and output of GRNs is complex and underpinned by an interplay between different regulatory layers. This regulatory information can be inferred genome-type by biochemical assays and short-reads sequencing.
I will talk about my current work using genome-wide high-throughput sequencing data to understand the regulatory logic that underpins animal development and how my lab is beginning to use different technologies to interrogate cell changes at single cell resolution.